The Seattle Seahawks visit the Arizona Cardinals on Sunday, September 20, in a Week 2 NFC West matchup during the 2026 NFL season. The game will be played at State Farm Stadium in Glendale, Arizona.
Both teams enter the divisional matchup at 1-0. Seattle defeated the New England Patriots 13-10 in Week 1, while Arizona opened the season with a 26-14 win over the Los Angeles Chargers.
Seattle Seahawks
Seattle enters the game after defeating New England in a matchup where its defense recorded three interceptions. Jaxon Smith-Njigba was the team's leading offensive contributor with eight receptions for 122 yards and a touchdown.
The biggest storyline for the Seahawks is at quarterback. Sam Darnold has been ruled out because of a glute injury, with Drew Lock set to start. Lock completed 16 of 22 passes for 187 yards and a touchdown during his Week 1 appearance.
Arizona Cardinals
Arizona opened the season with a 26-14 win over the Los Angeles Chargers. Jacoby Brissett completed 27 of 37 passes for 277 yards without an interception, while Trey McBride recorded nine receptions for 95 yards and a touchdown.
The Cardinals defense also made an impact in the season opener. Arizona now faces a Seattle offense adjusting to a change at quarterback.
Players and key factors
Drew Lock is one of the main players to watch after being named the starter in place of Darnold. Jaxon Smith-Njigba will also be an important part of Seattle's passing game following his 122-yard performance in Week 1.
For Arizona, Jacoby Brissett enters the matchup after a turnover-free performance. Trey McBride is another key piece for an offense looking to create opportunities against Seattle's defense.
Injuries and player status
Seattle will be without quarterback Sam Darnold because of a glute injury and safety Ty Okada because of a hamstring injury. Guard Anthony Bradford and safety Nick Emmanwori are listed as questionable.
Arizona cornerback Garrett Williams has been ruled out with an Achilles injury. Guards Isaiah Adams and Isaac Seumalo, defensive tackles Andrew Billings and Roy Lopez, cornerback Max Melton and safety Dadrion Taylor-Demerson are listed as questionable.
Rivalry history
This will be the 55th regular-season meeting between the Seahawks and Cardinals. Seattle holds a 31-22-1 advantage in the series.
Arizona has not defeated Seattle since November 2021 and enters this divisional matchup having lost nine consecutive games against the Seahawks.
Game Details
Game: Seattle Seahawks at Arizona Cardinals
Week: 2
Date: Sunday, September 20, 2026
Stadium: State Farm Stadium
City: Glendale, Arizona
Kickoff: 1:25 PM PT / 3:25 PM CT / 4:25 PM ET
USA TV: FOX
USA Streaming: FOX One