Dolphins vs 49ers: Week 2 Preview, USA TV Schedule and How to Watch NFL 2026

The Miami Dolphins visit the San Francisco 49ers on Sunday, September 20, in a Week 2 matchup during the 2026 NFL season. San Francisco will host its first regular-season home game of the campaign at Levi's Stadium.

The 49ers enter the matchup at 1-0 after defeating the Los Angeles Rams 27-7 in the season opener, while the Dolphins are 0-1 following a 27-13 loss to the Las Vegas Raiders.

Miami Dolphins

Miami opened the season with a loss to the Raiders. Malik Willis completed 20 of 36 passes for 220 yards, no touchdowns and one interception. He also added 39 rushing yards and a touchdown.

The Dolphins produced 259 total yards in their opener. De'Von Achane carried the ball 11 times for 36 yards, while rookie wide receiver Caleb Douglas stood out with five receptions for 94 yards.

Miami's defense intercepted two passes in Las Vegas but did not record a sack. The unit now faces a San Francisco offense that produced 379 total yards in Week 1.

San Francisco 49ers

San Francisco opened the season with a 27-7 victory over the Los Angeles Rams in Melbourne, Australia. Brock Purdy completed 73.5% of his passes for 205 yards, three touchdowns and one interception.

Christian McCaffrey led the 49ers rushing attack with 68 yards on 10 carries. San Francisco finished Week 1 with 379 total yards and controlled the ball for 33:50.

The matchup against Miami also marks San Francisco's return to Levi's Stadium after opening the season in Australia.

Players and key factors

Brock Purdy is one of the main players to watch after throwing three touchdown passes in Week 1. Christian McCaffrey will also be an important part of an offense looking to maintain balance between its passing and rushing attacks.

For Miami, Malik Willis will again lead the offense. Caleb Douglas enters the game after recording 94 receiving yards in his professional debut.

Injuries and player status

Miami will be without linebacker Ronnie Harrison because of a hamstring injury and linebacker Demeioun "Chop" Robinson because of a concussion. Long snapper Tucker Addington is questionable with a shoulder injury.

San Francisco will be without wide receiver De'Zhaun Stribling, who is out with an ankle injury. Running back Kaelon Black is questionable with a groin injury, while kicker Eddy Piñeiro is questionable because of an illness.

Series history

The Dolphins and 49ers will meet for the 17th time in the regular season. The all-time series is tied at eight wins apiece through the first 16 meetings.

The most recent meeting at Levi's Stadium came in 2022, when San Francisco won 33-17. That game is also remembered as Brock Purdy's first significant NFL action after Jimmy Garoppolo suffered an injury.